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Gene Therapy for Pleural Malignancies

Gene Therapy for Pleural Malignancies

Estimated reading time: < 1 min

Condition: Pleural Mesothelioma

Estimated Enrollment: 18

Gender: All

Min Age: 18 Years

Age Group: Adult, Older Adult

Current Status: Active, not recruiting

Study Results: No Results Available

Outcome Measures: To determine toxicity of two doses of intrapleural BG00001 (Ad.hIFN-β over 8 days, and,  To assess systemic and intrapleural cytokine responses as well as cellular and humoral immune responses after repeated BG00001 instillation,,  and to assess, in a preliminary way, efficacy via tumor regression, time to progression and survival.,

Interventions: Adenoviral-mediated Interferon-beta, SCH 721015


Study Type: Interventional

Study Design: Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: None (Open Label),Primary Purpose: Treatment

Primary Completion Date: April 2023

Completion Date: April 2023

Last  Posted Date: March 5, 2019

Location: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States

Website Link: https://ClinicalTrials.gov/show/NCT00299962

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